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1.
When a woman in on her period (aka "up on blocks"). Similar to "lockdown"
We can't have sex this weekend because my girlfriend is on blockdown.
von Anthony Gentile 30. April 2007
 
2.
When you block someone on your friends list.
Friend #1: "I'm tired of Joe posting sarcastic messages on my status updates."
Friend #2: "Girl! You need to put him on BlockDown!"
von Lolita75 16. Januar 2010