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1.
A particularly unpleasant hangover.
"Last night was great, but I have the worst case of the irish flu today."
von Melissa 10. Juli 2004
111 31
 
2.
A hangover, usually involving whiskey; may be mild or severe
"I’ve still got a touch of the Irish flu."

"The Irish flu?"

"Also known as a hangover."

(from "A Nose for Murder" by Lee Charles Kelley
von Lee Charles Kelley 6. April 2005
69 25
 
3.
The ailment one suffers on March 18th after properlyly celebrating St. Patrick's Day. Anyone of Irish descent may also use the term to denote a hangover on any day of the year.
Seamus: Ugh, I was out drinking Guinness until the wee hours. I think I'll call in with the Irish Flu today.
von robbie vienna 17. März 2009
19 14