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2.
A slang term for a grandfather. Used in many southern states, including Texas, Arkansas, Georgia, and Louisiana.
"Hey Pepa! Where you goin'?"

"I'm headin' back into the house to get your Mema."
von texarkanaborn 2. November 2012
 
1.
In Mexico: its one of several slang terms used for a girl's pussy a.k.a. vagina.

En Mexico es una palabra conocida como la chocha de una mujer.. alias Vagina.
1. She said her pepa gets wet when she gets aroused.

2. Ella dice que se le moja la pepa cuando se excita.
von chocu 28. November 2006
 
3.
In Colombia: A person whose intelligence is above the average.
Someone characterized for being smarter than others.
Carlos es el mas pepa de la clase.
von Mario F Monsalve 12. Dezember 2005
 
4.
A nickname for someone's grandfather.
Me: "Aunt Maria, have you seen Pepa?"

Aunt Maria: "Yeah, he went out with Mema."
von CrystellaMarie 23. Oktober 2008