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1.
In American football, a pick 6 is when an interception is made and returned for a touchdown (i.e., 6 points).
Tracy Porter got a pick 6 in Superbowl XLIV
von cajunchick 30. April 2010
 
2.
A play in football where the quarterback throws an interception and the defense returns it for a touchdown
God damn it! Chris Turner threw another pick 6!
von nhl_nfl_nba 24. Oktober 2009