Top Definition
The systematic wasting away of brain matter
Guy 1: What is with him recently?

Guy 2: He's been doing a lot of drugs, caught crabs and has Poseidon's Disease.

Guy 1: That explains why he's getting stupider
#posedion #dullard #stupid #wasting #disease #dimentia
von MamboNZ 7. April 2009
6 Words related to Poseidon's Disease
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