Top Definition
a. Deliberately putting someone an unfavorable situation that he/she would not like.
I decided to screw him over by stealing his test and changing all the answers.

Hey, kid, I'll give you $100 if you screw over your English teacher. He got me fired from my job!

The best way to screw over an innocent guy is to frame him and put him in jail.
von Melvin720 21. September 2009

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