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To have a foreign object or other obstruction in the way of personal space. It can also be used to describe an intrusion or some interruption.
"Yo, homie what you be doin' getting all up in my grillz!?"

"Hey Clarence check out those wasps all up in the grillz!"
von MP21 26. September 2009

Words related to Up in the grillz!

gangsta homie interrupt lol obstruct