The growth of an inflammed, festered, and bloody hemorrhoid that creates a groove-like affect in your feces.
Dave, don't do it. Jeff has an ass knuckle, that's not going to be fun.
von Sean Piner 30. September 2006
Someone who is clueless or stupid.
"Dude the new guy is such a dumbass!

"for real, he's a total friggin' ass-knuckle!
von Skin bone 21. Mai 2011

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