Top Definition
To administer a psychoactive drug rectally.
Idiot: Booty bumping tweak is awesome!

Idiot with deathwish: Stop being stupid. It's all about mainlining.
von Not an idiot 10. Juli 2006
1 more definition
when one shakes ones ass against another's ass and vibrations in between would result in a booty bumping.
"I was shaking my thang, when this chick suddenly grinding in my space booty bumping."
von Jaysin and ahmanduh 28. August 2009

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