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1.
Acronym for 'Crying My Face Off.' Often used in games after losing to another player or when speaking emotionally online about relationships or anything related to crying.
I can't believe I lost! I'm going to bed CMFO.

When she dumped me I was CMFO, but later I was like WTF!?
von mercboyan 26. September 2008
 
2.
Chief Mother Fucking Officer
That lady killer just made it rain again at the club tonight -he is one CMFO
von El Jefe CMFO 3. August 2010