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15.
the defensive act of castrating someone in order to prevent sexual advances. First used in Questionable Content comic number 36.
I had to defenestrate my roommate before he tried to sleep with me.
von RoblingRobot 10. November 2009
 
16.
to reduce to utter ruin or nonexistence; destroy utterly; to molliwhop something real nice
After the Mark made a comment about Sean's sister, Sean defenestrated him. Mark was last seen missing two teeth and with a nice shiner.
von Soheil Saeed 26. Februar 2008
 
17.
To quickly close a computer window so as to prevent your boss/girlfriend/etc. from seeing it.
I was checking out some hot girl on girl porn on the internet when my girl suddenly came home and I had to defenestrate it right quick.
von Windoze XP 25. März 2005
 
18.
To uninstall software from a Microsoft operating system, usually in frustration.
I couldn't get that program to do what I needed it to, so I defenestrated it and installed something better.
von jsgarvin 23. September 2010
 
19.
To throw something out of a large window.
"My God man, if you don't SHUT UP, I will defenestrate you."
von Awesome Socks Man Boy Kid Guy 9. September 2014