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1.
to distinguish from similar options
What differentiated this start-up portal was a relationship with urbandictionary.com
von Alexander Zubatov 17. März 2007
 
2.
Another word for difference.
J: Wow she looks a lot like her sister.
Y: Yea it's hard to differentiate.

(difficult to see the difference)
von Rebanex 5. März 2008
 
3.
Used as a verb in a threatening tone, can be used to mean "fuck up," "kill," etc...
You fuckin' touch me again and I'll differentiate ya!
von Jason McAaron 14. Mai 2008