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1.
Pretty much an accurate description of the Presidency of George W. Bush.
The economy, No Child Left Behind, the Iraq war, the budget, and the tax cuts are all example of Bush's numerous fuck ups.
von Jesse 24. Januar 2005
 
2.
A failure, someone who really messes up.
Omg you're such a fuck up.
von FreD 23. Juli 2004
 
3.
1. To make a mistake; bungle something.
2. To act carelessly, foolishly, or incorrectly.
3. To cause to be intoxicated.
Fucked up fucker.
von Sam429 12. März 2004
 
4.
An extreme disappointment, someone who continually makes foolish mistakes and doesn't learn.
"Dave was a fuckup. He was constantly ruining good situations for selfish reasons."

von LKR 29. Dezember 2005
 
5.
A failure at everything, total loser, unable to do anything right
Barry you fuck up!
von Barry... how ironic? 28. März 2003
 
6.
1) Mess up, screw up, failure, mistake
2) Also can be used to say shut up in a more excessive way
1) You're a total fuck up
2) Shut the fuck up!
von Whale watcher 22. April 2003
 
7.
A complete elmore or screw up.
You, sir, are a complete and utter fuck up. Good day!
von James Bullwinkle 26. September 2007