To possess large arms; when one's arms are particularly large.... for instance after lifting weights. Derived from the word "guns" (or arms).
Tamara: "Nick, where have been all fukkin' day?"
Nick: "Chill out, big girl. I've been pumpin' some iron."
Tamara: "I can tell. You look all gunned up, you handsome devil."
von Dan Moses 16. August 2007

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