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1.
Slang term for something of big time, major, gigantic or huge proportions.
Hey baby, you got some major league hooters.
von JohnstonGuy 20. Juni 2005
 
2.
feces. crap. poop. bowel movement number 2.
Joe: Ah man i gotta take a major league!
Andy: You gotta league it?
von lizzynicz 28. Mai 2009