A Mike Tyson Sandwich is a Sandwich that's loaded with breaded deep fried chunks of Ribeye Steak, lettuce, tomato, onions, bacon, melted swiss cheese, and dijon mustard all served on a toasted Sub Roll that is at least 12" long. It was reportedly invented at Sam's Tavern in Lansing, Michigan. It's supposedly called the "Mike Tyson" Sandwich, because due to it's Fried Steak, Bacon, and Cheese combo, it will knock your heart the fuck out, much like Mike Tyson would.
When I had a Mike Tyson Sandwich in Canada....I mean, Michigan, it was like this:

I had a four foot long "Mike Tyson" Sandwich at Sam's Tavern in Lansing, Michigan and about 10 minutes afterwards I had nuclear diarrhea in the toilet that stunk like a open sewer line
von Da Wizard Of OZ 22. November 2009

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