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1.
The act of using heroin interveniously.
I heard Joe was all shot up.
von stillalive 13. September 2007
 
2.
The act of being high with drugs of any sort, usually heroin. For example, you can get shot up or be shot up.
"I got shot up yesterday."
"I shot up last night."
von addictedtoheroinbishes 28. Februar 2010
 
3.
To be high because of drugs.
"Man, I'm so shot up!"
von Omnomnom1112 1. März 2010
 
4.
When pimples look like little bullet wounds aka pimples are crazy
o shit you see dudes face it got shot up crazy
von P.O.P 17. Januar 2008