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1.
(noun) the act of performing sexual intercourse,acts, or favors using skype including, but not limited to the following: stripping, masturbating, dirty talk, licking the camera, licking anything, food sex, inserting objects into body orifices,or doing one's taxes.
Sam: Jane, would you like to have skypersex?

Jane: Yes, let me first close all the windows on my screen.

Sam: Ooh skype me you dirty bitch!
von Shulie and Bone 6. Dezember 2007
 
2.
Cyber sex over Skype or other VoIP services.
"Oh harder bab... Oh damn it my microphone is acting up, I gotta refresh Skype to keep up this hot Skypersex."
von Cornelius Frump III 20. Mai 2008
 
3.
Having cyber sex via the Skype(tm) program, particularly when a web cam is involved.
Tito and I were really into our SkyperSex last night... it woke up my parents"
von Loki's Mom 12. Februar 2008
 
4.
Sexual acts done while using the program skype, similar to cyber sex
Flora: I want cyber sex!
Rex: I want skype and sex!
Flora: How about cyber sex mixed with skype?
Rex: You mean skyper sex?!
von Danny Blaine 25. Oktober 2011