Top Definition
Short for staphylococcus, a bacteria which can live harmlessly on skin surfaces however when the skin is broken, staph bacteria can enter the wound causing infection. Causes; Aly G.
There's Staph infection outbreak in southern NY, Bianca has it!
von JimJaydansy 14. November 2007
1 more definition
A total closet bitch.
Be sure to take care of the bill or the staphinfection will get you.
von doveshack 1. August 2011

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